Hydroxy-substituted cephalosporins
OwnerToshiyasu Ishimaruinventor
Life of this patent
Estimating the term…
Abstract
Hydroxy-substituted cephalosporins, particularly 7-(.alpha.-hydroxy-arylacetamido)-3-substituted-3-cephem-4-carboxylic acids of the formula: ##STR1## wherein R is a hydrogen atom, an esterified carboxy or carboxy group, and Y is a lower alkanoyl, lower alkoxy or azido group or a group of the formula: --SR.sub.3 in which R.sub.3 is a heterocyclic residue. These compounds have antibacterial activity against Gram-positive and Gram-negative bacteria.
Claims8
A compound of the formula ##STR6## wherein R' is carboxy, p-methoxy-benzyloxycarbonyl, ethoxycarbonyl, 2-methyl-propoxycarbonyl, p-nitrobenzyloxy-carbonyl 2,2,2-trichloroethoxycarbonyl, phenacyloxycarbonyl, diacetylmethoxycarbonyl, 1-methoxycarbonyl-2oxopropan-1-yl-oxycarbonyl, and 1-ethoxycarbonyl-2-oxopropan-1-yl-oxycarbonyl, and
- R.sub.3 is a heterocycle selected from the group consisting of the thiadiazolyl, tetrazolyl, triazolyl, oxadiazolyl, oxopyridinyl, imidazolyl and pyrimidinyl groups, and the corresponding methyl-substituted thiadiazolyl, tetrazolyl, triazolyl, oxadiazolyl, oxopyridinyl, imidazolyl and pyrimidinyl groups,
- and pharmaceutically acceptable non-toxic salts thereof.
7-(.alpha.-hydroxy-4-carboxyphenylacetamido)-3- (5-methyl-1,3,4-thiadiazol-2-yl)thiomethyl-3-cephem-4-carboxylic acid.
Dependencies are inferred from the claim text.