Novel 3-(oxygenated alkyl)-1,9-dihydroxy and 1-hydroxy-9-keto dibenzo[b,d]p y
AssigneeEli Lilly and Company
InventorsDavid S. Fukuda, Bernard J. Abbott, Robert A. Archer
Life of this patent
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Abstract
1-Hydroxy-9-keto-3-alkyl-dibenzo[b,d]pyrans or 1,9-dihydroxy-3-alkyl-dibenzo[b,d]pyrans are oxygenated on the penultimate carbon of the alkyl side chain by fermentation with a strain of the micro-organism Bacillus cereus.
Claims4
The fermentation process which comprises subjecting as a substrate a compound of the formula ##STR3## wherein X and Y are either both hydrogen or one is hydrogen and the other methyl, wherein n is 1, 2, 3 or 4 and wherein, when taken singly, one of R and R' is H and the other is OH and when taken together, form the oxygen of a ketone group to the oxygenating activity of a strain of the micro-organism Bacillus cereus to produce an oxygenated compound of the formula ##STR4## wherein X and Y are either both hydrogen or one is hydrogen and the other methyl;
- wherein, when taken singly, one of the pair R and R' and one of the pair R" and R'" is H and the other is OH and, when taken together, the pair R and R' and the pair R" and R'" form the oxygen of a ketone group, the pairs R, R' and R", R'" being the same or different;
- and wherein n is 1, 2, 3, or 4.
Dependencies are inferred from the claim text.