Test strip for the detection of occult blood in excreta
AssigneeShionogi & Co., Ltd.
InventorsYasunao Ogawa, Yukio Yonetani
Life of this patent
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Abstract
A test strip for detecting the presence of occult blood in excreta such as urine or feces or body fluid, which strip comprises a bibulous or porous material impregnated with a chromogen, a hydroperoxide and, as a sensitizer, a thiazole compound of the formula: ##STR1## wherein R.sub.1 is a lower alkyl; a substituted or unsubstituted aralkenyl, or a substituted or unsubstituted aralkyl; R.sub.2 and R.sub.3 are each a hydrogen or a lower alkyl; and R.sub.2 and R.sub.3, when taken together with the adjacent carbon atoms, may form a benzene ring.
Claims18
A test strip for detecting occult blood in excreta or body fluids, which strip comprises a porous or bibulous absorbing material impregnated with a chromogen, a hydroperoxide and, as a sensitizer, a thiazole compound (I) of the formula:
- ##STR6## wherein R.sub.1 is a lower alkyl, a substituted or unsubstituted aralkenyl, or a substituted or unsubstituted aralkyl;
- R.sub.2 and R.sub.3 are each a hydrogen or a lower alkyl;
- and R.sub.2 and R.sub.3, when taken together with the adjacent carbon atoms, may form a benzene ring.
A test strip for occult blood in excreta or body fluids comprising a bibulous or porous absorbing material impregnated with an emulsion which is composed of 25% (w/v) gum arabic, 5% (w/v) sodium lauryl sulfate, cumene hydroperoxide, 10% (w/v) gelatine-0.2M citrate buffer (pH 5.0), 1% (w/v) tartrazine/aqueous ethanol and 2M citric acid-N-ethylmorpholine (pH 5.5) and after drying, with a solution which is composed of o-tolidine, 2-styryl-4-methylthiazole and chloroform.
A process for preparing a test strip for occult blood in excreta or body fluids which comprises impregnating a porous or bibulous absorbing material with a solution containing essentially a chromogen, a hydroperoxide and, as a sensitizer, a thiazole compound (I) of the formula:
- ##STR9## wherein R.sub.1 is a lower alkyl, a substituted or unsubstituted aralkenyl, or a substituted or unsubstituted aralkyl;
- R.sub.2 and R.sub.3 are each a hydrogen or a lower alkyl;
- and R.sub.2 and R.sub.3, when taken together with the adjacent carbon atoms, may form a benzene ring.
A process for preparing a test strip for occult blood in excreta or body fluids, wherein the hydroperoxide is a member selected from the group consisting of cumene hydroperoxide, p-menthane hydroperoxide, tetraline hydroperoxide, tert-butyl hydroperoxide, 2,4-dimethylhexane-2,5-dihydroperoxide and diisopropyl-benzene hydroperoxide.
A process for preparing a test strip for occult blood in excreta or body fluids, which comprises impregnating a bibulous or porous absorbing material with an emulsion which is composed of 25% (w/v) gum arabic, 5% (w/v) sodium lauryl sulfate, cumene hydroperoxide, 10% (w/v) gelatine-0.2M citrate buffer (pH 5.0), 1% (w/v) tartrazine/aqueous ethanol and 2M citric acid-N-ethylmorpholine (pH 5.5);
- drying the impregnated and absorbed material;
- impregnating the said material with a solution which is composed of o-tolidine, 2-styryl-4-methylthiazole and chloroform;
- and drying the resultant material to give the desired test strip.
A composition for occult blood determination, which comprises a chromogen, a hydroperoxide and, as a sensitizer, a thiazole compound (I) of the formula:
- ##STR12## wherein R.sub.1 is a lower alkyl, a substituted or unsubstituted aralkenyl, or a substituted or unsubstituted aralkyl;
- R.sub.2 and R.sub.3 are each a hydrogen or a lower group;
- and R.sub.2 and R.sub.3, when taken together with the adjacent carbon atoms, may form a benzene ring.
A method for detecting occult blood in excreta or body fluids, which comprises contacting the excreta or body fluids with a test strip or a composition comprising a chromogen, a hydroperoxide and, as a sensitizer, a thiazole compound (I) of the formula:
- ##STR15## wherein R.sub.1 is an alkyl, a substituted or unsubstituted aralkenyl, or a substituted or unsubstituted aralkyl;
- R.sub.2 and R.sub.3 are each a hydrogen or a lower alkyl;
- and R.sub.2 and R.sub.3, when taken together with the adjacent carbon atoms, may form a benzene ring.
Dependencies are inferred from the claim text.