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US 4,063,023 AGranted
Process for preparing 4-(hydroxymethyl)imidazole compounds
AssigneeSK&F Lab Co.
InventorsElvin L. Anderson, Wilford L. Mendelson, George R. Wellman
Life of this patent
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Abstract
An improved process for the preparation of 4-(hydroxymethyl)imidazoles by reducing 4-imidazolecarboxylic acid esters using an alkali metal or calcium in liquid ammonia with an additional proton source provided during the reaction or upon workup.
Claims11
A process for the preparation of a 4-(hydroxymethyl)imidazole compound of the formula:
- ##STR2## in which R is hydrogen or lower alkyl, which comprises reducing a 4-imidazolecarboxylic acid ester of the formula:
- ##STR3## in which R is as defined above and R' is lower alkyl, using an alkali metal or calcium in liquid ammonia with an additional proton source.
Dependencies are inferred from the claim text.