[[[(2,4-Dioxo-1-imidazolidinyl)amino]carbonyl]amino]-acetylcephalosporin derivatives
AssigneeE. R. Squibb & Sons, Inc.
InventorsHermann Breuer, Uwe D. Treuner
Life of this patent
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Abstract
[[[(2,4-Dioxo-1-imidazolidinyl)amino]carbonyl]amino]-acetylcephalosporin derivatives having the formula ##STR1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, diphenyl-lower alkyl, tri(lower alkyl)silyl, trihaloethyl, a salt forming ion, or the group ##STR2## R.sub.1 is hydrogen or methoxy; R.sub.2, R.sub.3 and R.sub.5 each is hydrogen or lower alkyl; R.sub.4 is hydrogen, lower alkyl, cyclo-lower alkyl, cyclo-lower alkenyl, cyclo-lower alkadienyl, phenyl, phenyl-lower alkyl, substituted phenyl, substituted phenyl-lower alkyl, or certain heterocyclic groups; R.sub.6 is lower alkyl; and X is hydrogen, lower alkanoyloxy, ##STR3## or certain heterothio groups; are useful as antibacterial agents.
Claims12
A compound of the formula ##STR231## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, diphenyl-lower alkyl, tri(lower alkyl)silyl, trihaloethyl, aluminum, alkali metal, alkaline earth metal, phenyl-lower alkylamine, lower alkylamine, tri(lower alkyl)amine, N-lower alkylpiperidine or ##STR232## R.sub.1 is in the .alpha.-configuration and is hydrogen or methoxy;
- R.sub.2, R.sub.3 and R.sub.5 each is hydrogen or lower alkyl;
- R.sub.4 is hydrogen, lower alkyl, cyclo-alkyl of 3 to 7 carbons, cycloalkenyl of 3 to 7 carbons, cycloalkadienyl of 6 or 7 carbons, phenyl, phenyl-lower alkyl, substituted phenyl or phenyl-lower alkyl wherein said phenyl substituent is one or two members selected from the group consisting of halogen, lower alkyl, lower alkoxy and hydroxy, or a mono substituted or unsubstituted heterocyclic selected from the group consisting of 2-thienyl, 3-thienyl, 2-furyl, 3-furyl, 2-pyridyl, 3-pyridyl and 4-pyridyl wherein said heterocyclic substituent is attached at an available carbon atom and is halogen or lower alkyl;
- R.sub.6 is lower alkyl;
- and X is a heterothio group selected from the group consisting of ##STR233## wherein R.sub.7 is hydrogen or lower alkyl and R.sub.8 is hydrogen, lower alkyl, methoxy, hydroxy or halogen.
Dependencies are inferred from the claim text.