US 4,062,978 A · Phenyl butanones

Abstract

Anti-inflammatory compositions are prepared which comprise a therapeutically effective amount of a compound of the formula ##STR1## wherein X is CO or CHOH; Y is CO, an oxygen atom or a direct bond; the dotted line represents a double bond which is optionally present when Y is an oxygen atom or a direct bond; R.sub.1 is hydrogen or methyl; R.sub.2 is hydrogen, fluorine, chlorine, bromine, methyl, trifluoromethyl, methoxyl, hydroxyl, acetoxyl, nitro or amino; R.sub.3 is alkyl of 3-8 carbon atoms, cycloalkyl of 3-8 carbon atoms, alkenyl of 3-8 carbon atoms, cycloalkenyl of 5-8 carbon atoms, phenyl or phenyl substituted by 1 or 2 substituents selected from the group consisting of fluorine, chlorine, bromine, methyl, ethyl, methoxyl, ethoxyl, benzyloxyl, hydroxyl, acetoxyl, trifluoromethyl, nitro, amino, acetyl, methylthiol, methylsulphonyl, methylamino and dimethylamino. Compounds of the above formula are novel except that R.sub.1 must be methyl: when R.sub.3 -- Y is a 4-phenyl group, R.sub.2 is hydrogen and X is CO; when R.sub.3 -- Y is a 4-benzyl group and R.sub.2 is hydrogen; and also when R.sub.3 -- Y is a 3-benzoyl group, R.sub.2 is hydrogen and X is CO.

Claims23

Dependent claims

A pharmaceutical composition useful for the treatment of inflammation in humans and animals which comprises an anti-inflammatory amount of a compound of the formula ##STR16## wherein X is CO;

Y is an oxygen atom;
the dotted line represents a double bond which may be present or absent;
R.sub.1 is hydrogen or methyl;
R.sub.2 is hydrogen;
and R.sub.3 is alkenyl of 3 to 8 carbon atoms or cycloalkenyl of 5 to 8 carbon atoms, in combination with a pharmaceutically acceptable carrier.

2 more elements

Dependencies are inferred from the claim text.

Phenyl butanones

Life of this patent

Phenyl butanones

Life of this patent

Abstract

Claims23