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US 4,062,964 AGranted
Antifertility-combinations
AssigneeCiba-Geigy Corporation
InventorBernard George Steinetz, Jr.
Life of this patent
Estimating the term…
Abstract
Sub-abortifacient doses of .alpha.-(4-aminophenyl)-.alpha.-lower alkylglutarimides and natural prostaglandins or corresponding 9-oxa or 9-thiaprostaglandins, when given in combination to impregnated female mammals in the early period of gestation, or after a missed menses, terminate pregnancy effectively and without undue side effects.
Claims9
A pharmaceutical antifertility composition comprising:
- (a) a pharmacological amount of an .alpha.-(4-aminophenyl)-.alpha.-lower alkylglutarimide, or its lower alkanoyl derivative corresponding to Formula I ##STR4## wherein R is lower alkyl and Y is hydrogen or lower alkanoyl, or a therapeutically acceptable acid addition salt thereof;
- (b) a pharmacological amount of a natural prostaglandin, or analogs thereof corresponding to Formula II ##STR5## wherein A is methylene, ethylene or ethenylene, X is carbonyl, hydroxymethylene, oxa, thia, sulfinyl or sulfonyl, each of R.sub.1 and R.sub.2 is hydrogen or lower alkyl, each of R and R.sub.3 are an aliphatic, cycloaliphatic, cycloaliphatic-aliphatic or araliphatic radical or R is hydrogen or one base-equivalent, whereby both of said amounts together are so selected to cause interception in mammals and (c) a pharmaceutical excipient for oral or parenteral administration.
Dependencies are inferred from the claim text.