Pharmaceutical compositions and methods of inhibiting phenylethanolamine N-methyltransferase
AssigneeSmithKline Corporation
InventorsCarl Kaiser, Robert G. Pendleton
Life of this patent
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Abstract
Pharmaceutical compositions and methods of inhibiting phenylethanolamine N-methyltransferase using 7 and/or 8 substituted 1,2,3,4-tetrahydroisoquinoline compounds.
Claims8
A pharmaceutical composition to inhibit phenylethanolamine N-methyltransferase comprising a pharmaceutical carrier and, in an effective amount to inhibit phenylethanolamine N-methyltransferase, a tetrahydroisoquinoline compound of the formula:
- ##STR3## in which:
- R.sub.1 and R.sub.2 are both trifluoromethyl or R.sub.1 is sulfamoyl and R.sub.2 is hydrogen
- R.sub.3 and R.sub.4 are hydrogen or a pharmaceutically acceptable, acid addition salt thereof.
A method of inhibiting phenylethanolamine N-methyltransferase which comprises administering to an animal, in an amount sufficient to inhibit phenylethanolamine N-methyltransferase, a tetrahydroisoquinoline compound of the formula:
- ##STR4## in which:
- R.sub.1 and R.sub.2 are both trifluoromethyl or R.sub.1 is sulfamoyl and R.sub.2 is hydrogen and
- R.sub.3 and R.sub.4 are hydrogen or a pharmaceutically acceptable, acid addition salt thereof.
A method of reducing the formation of epinephrine in an animal under stress which comprises administering to said animal, in amount sufficient to reduce the formation of epinephrine, a tetrahydroisoquinoline compound of the formula:
- ##STR5## in which:
- R.sub.1 and R.sub.2 are both trifluoromethyl or R.sub.1 is sulfamoyl and R.sub.2 is hydrogen and
- R.sub.3 and R.sub.4 are hydrogen or a pharmaceutically acceptable, acid addition salt thereof.
Dependencies are inferred from the claim text.