Various 2-substituted-1H-benz[de]isoquinoline-1,3(2H)-diones
AssigneeE. R. Squibb & Sons, Inc.
InventorsPeter C. Wade, Berthold Richard Vogt
Life of this patent
Estimating the term…
Abstract
Compounds of the following formula and their acid addition salts ##STR1## A is straight or branched chain alkylene of 2 to 6 carbons; R.sub.1 and R.sub.2 are located at the 7 or 8 and 5 or 6 position respectively and are independently selected from the group consisting of hydrogen, straight or branched chain alkyl of 1 to 4 carbons, straight or branched chain alkoxy of 1 to 4 carbons, Cl, Br, F, amino, nitro, cyano, and CF.sub.3 ; R.sub.3 and R.sub.4 are independently selected from the group consisting of hydrogen and straight or branched chain alkyl of 1 to 4 carbons; and n is 1, 2, or 3; m is 1 or 2; are disclosed. These compounds possess anti-protozoal activity.
Claims17
A compound of the formula ##STR19## wherein A is straight chain alkylene of 2 to 4 carbons;
- and a pharmaceutically acceptable acid addition salt thereof.
A compound of the formula:
- ##STR20## wherein Z is ##STR21## A is straight or branched chain alkylene of 2 to 4 carbons;
- R.sub.1 and R.sub.2 are located at the 7 or 8 and 5 or 6 position respectively and are independently selected from the group consisting of hydrogen, methyl, methoxy, Cl, Br, and F;
- and a pharmaceutically acceptable acid addition salt thereof.
A compound of the formula:
- ##STR22## A is straight or branched chain alkylene of 2 to 4 carbons;
- R.sub.1 and R.sub.2 are located at the 7 or 8 and 5 or 6 position respectively and are independently selected from the group consisting of hydrogen, methyl, methoxy, Cl, Br, and F;
- R.sub.3 and R.sub.4 are independently selected from the group consisting of hydrogen and methyl;
- and a pharmaceutically acceptable acid addition salt thereof.
A compound of the formula:
- ##STR23## wherein n is 1, 2, or 3;
- A is straight or branched chain alkylene of 2 to 4 carbons;
- R.sub.1 and R.sub.2 are located at the 7 or 8 and 5 or 6 position respectively and are independently selected from the group consisting of hydrogen, methyl, methoxy, Cl, Br, and F;
- and a pharmaceutically acceptable acid addition salt thereof.
A compound of the formula:
- ##STR24## wherein m is 1 or 2;
- A is straight or branched chain alkylene of 2 to 4 carbons;
- R.sub.1 and R.sub.2 are located at the 7 or 8 and 5 or 6 position respectively and are independently selected from the group consisting of hydrogen, methyl, methoxy, Cl, Br, and F;
- and a pharmaceutically acceptable acid addition salt thereof.
A pharmaceutical composition useful for treating mammals having a protozoa infection comprising a pharmaceutically acceptable carrier and a compound or mixture of compounds of the formula:
- ##STR26## A is straight or branched chain alkylene of 2 to 6 carbons;
- R.sub.1 and R.sub.2 are located at the 7 or 8 and 5 or 6 position respectively and are independently selected from the group consisting of hydrogen, straight or branched chain alkyl of 1 to 4 carbons, straight or branched chain alkoxy of 1 to 4 carbons, Cl, Br, F, amino, nitro, cyano, and CF.sub.3 ;
- R.sub.3 and R.sub.4 are independently selected from the group consisting of hydrogen and straight or branched chain alkyl of 1 to 4 carbons;
- n is 1, 2, or 3;
- m is 1 or 2;
- and a pharmaceutically acceptable acid addition salt thereof.
Dependencies are inferred from the claim text.