Parasiticidal animal dip compositions protected against microbial buildup
AssigneeRohm and Haas Company
InventorAndrew B. Law
Life of this patent
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Abstract
Animal dip compositions which comprise a veterinary parasiticide and a carrier are protected against the buildup of microorganisms by the presence of a 2-alkyl-aryl- or aralkyl-3-isothiazolone or 3-hydroxyisothiazol or their salts with strong acids or their metal salt complexes.
Claims25
An animal dip composition protected against the buildup of microorganisms which comprises a veterinary animal dip parasiticide, an acceptable carrier, and an effective amount of a compound of the formula ##STR5## wherein Y is a hydrogen atom, a (C.sub.1 -C.sub.18)alkyl group, a (C.sub.6 -C.sub.10)aryl group, or a (C.sub.7 -C.sub.10)aralkyl group,
- R is a hydrogen atom, a halogen atom, or a (C.sub.1 -C.sub.4)alkyl group,
- R' is a hydrogen atom, a halogen, or a (C.sub.1 -C.sub.4)alkyl group, or
- R and R' can be taken together to complete a benzene ring, optionally substituted with one or more halogen atoms, nitro groups, (C.sub.1 -C.sub.4)alkyl groups, cyano groups, or (C.sub.1 -C.sub.4)alkoxy groups;
- a salt of a compound of formula I with a strong inorganic or organic acid, or a metal salt complex of an isothiazolone having the formula ##STR6## wherein Y, R, and R' are as defined above,
- M is a cation of barium, calcium, lithium, magnesium, sodium or strontium;
- X is an anion forming a compound with the cation M, in which the compound has sufficient solubility to form a complex of the invention;
- a is the integer 1 or 2;
- and
- n is an integer which for the anion X satisfies the valence of the cation M.
A method of controlling microorganisms in a veterinary parasiticidal animal dip composition containing a veterinary parasiticide which comprises adding to the dip composition an effective amount of a compound of the formula ##STR7## wherein Y is a hydrogen atom, a (C.sub.1 -C.sub.18)alkyl group, a (C.sub.6 -C.sub.10)aryl group, or a (C.sub.7 -C.sub.10)aralkyl group,
- R is a hydrogen atom, a halogen atom, or a (C.sub.1 -C.sub.4)alkyl group,
- R' is a hydrogen atom, a halogen, or a (C.sub.1 -C.sub.4)alkyl group, or
- R and R' can be taken together to complete a benzene ring, optionally substituted with one or more halogen atoms, nitro groups, (C.sub.1 -C.sub.4)alkyl groups, cyano groups, or (C.sub.1 -C.sub.4)alkoxy groups;
- a salt of a compound of formula I with a strong inorganic or organic acid, or a metal salt complex of an isothiazolone having the formula ##STR8## wherein Y, R, and R' are as defined above,
- M is a cation of barium, calcium, lithium, magnesium sodium or strontium;
- X is an anion forming a compound with the cation M, in which the compound has sufficient solubility to form a complex of the invention;
- a is the integer 1 or 2;
- and
- n is an integer which for the anion X satisfies the valence of the cation M.
A method of preventing bacterial and fungal cross-contamination of animals during treatment of the animals with a veterinary parasiticidal animal dip composition containing a veterinary parasiticide which comprises adding to the dip composition an effective amount of a compound of the formula ##STR9## wherein Y is a hydrogen atom, a (C.sub.1 -C.sub.18)alkyl group, a (C.sub.6 -C.sub.10)aryl group, or a (C.sub.7 -C.sub.10)aralkyl group,
- R is a hydrogen atom, a halogen atom, or a (C.sub.1 -C.sub.4)alkyl group,
- R' is a hydrogen atom, a halogen, or a (C.sub.1 -C.sub.4)alkyl group, or
- R and R' can be taken together to complete a benzene ring, optionally substituted with one or more halogen atoms, nitro groups, (C.sub.1 -C.sub.4)alkyl groups, cyano groups, or (C.sub.1 -C.sub.4)alkoxy groups;
- a salt of a compound of formula I with a strong inorganic or organic acid, or a metal salt complex of an isothiazolone having the formula ##STR10## wherein Y, R, and R' are as defined above,
- M is a cation of barium, calcium, lithium, magnesium, sodium or strontium;
- X is an anion forming a compound with the cation M, in which the compound has sufficient solubility to form a complex of the invention;
- a is the integer 1 or 2;
- and
- n is an integer which for the anion X satisfies the valence of the cation M.
Dependencies are inferred from the claim text.