Mixture of antibiotics produced by new species of micromonospora
AssigneePfizer Inc.
InventorsWalter D. Celmer, Frank C. Sciavolino, Walter P. Cullen, John B. Routien
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Abstract
A new species of Micromonospora, designated Micromonospora lacustris sp. nov. Routien, when subjected to submerged aerobic fermentation under controlled conditions, produces a mixture of at least 13 antibiotics. Two of these antibiotics are rifamycin S and rifamycin SV. Two other members of the antibiotic mixture are the 3-methylthio derivatives of rifamycin S and rifamycin SV.
Claims1
Antibiotic substance Compound 32,656 which in crystalline form dissolved in 0.01 M HCl in methanol exhibits absorption maxima in the ultraviolet light region of the spectrum at 225, 253 (inflection), 300 and 414 .mu. with E.sub.1% values of 465, 280, 290 and 150 respectively;
- having the average composition by weight of 58.19% carbon, 5.97% hydrogen, 3.17% nitrogen, 3.52% sulfur and 29.15% oxygen (by difference);
- and when pelleted in KBr exhibits characteristic absorption in the infrared region at the following wavelengths in microns:
- 2.90, 3.40, 5.75, 6.05, 6.30, 6.60, 6.80, 6.95, 7.25, 7.55, 7.95, 8.65, 9.40, 10.25, 10.55, 11.35, 12.45 and 13.20.
Dependencies are inferred from the claim text.