Chroman derivatives

Abstract

Compounds of the formula ##STR1## wherein R.sub.3 is hydrogen, halogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkoxyl of 1 to 6 carbon atoms, alkenyloxyl of 2 to 6 carbon atoms, alkylthio of 1 to 6 carbon atoms, hydroxyl, amino, alkylamino of 1 to 6 carbon atoms, dialkylamino of 1 to 6 carbon atoms, nitro, trifluoromethyl, acylamino of 2 to 7 carbon atoms, alkoxysulphonylamino of 1 to 6 carbon atoms, carboxyl, nitrile, AOR.sub.4, ASR.sub.7, ASO.sub.2 R.sub.7, ANHR.sub.7, ANR.sub.7 COR.sub.8, ANR.sub.7 SO.sub.2 R.sub.8 or ANR.sub.7 CO.sub.2 R.sub.8, wherein A is alkylene of 1 to 4 carbon atoms, R.sub.7 is alkyl of 1 to 4 carbon atoms and R.sub.8 is alkyl of 1 to 4 carbon atoms; R.sub.4 is hydrogen or halogen; or R.sub.3 together with R.sub.4 forms a --CH.dbd.CH--CH.dbd.CH--, --NH--CH.dbd.CH--, --CH.sub.2 --CH.sub.2 --CH.sub.2 --CH.sub.2 -- or --CH.sub.2 --CH.sub.2 --CH.sub.2 --CO-- system; R.sub.5 is hydrogen, alkyl of 1 to 6 carbon atoms or phenyl; and R.sub.5 is hydrogen, alkyl of 1 to 6 carbon atoms or phenyl. Are useful as intermediates for producing derivatives of trans-3-hydroxy-4-amino-chroman which derivatives are useful for their blood pressure lowering activity and anti-hypertensive activity. CROSS-REFERENCE

Dependencies are inferred from the claim text.