Process for preparation of tryptophols
AssigneeJohn Wyeth & Brother Limited
InventorGeorge Oliver Weston
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Abstract
A process for preparing tryptophol derivatives comprises reducing a 3-indolylglyoxylic acid ester or acid halide using an alkali metal borohydride in the presence of an alcohol or ether solvent. The tryptophol derivatives prepared are useful as intermediates to pharmacologically active compounds.
Claims9
A process for preparing a 1-unsubstituted-3-(2-hydroxyethyl)indole which comprises reducing a 1-unsubstituted-3-indoleglyoxylic acid ester or acid halide with an alkali metal borohydride in the presence of a solvent selected from alkanols of 2 to 6 carbon atoms;
- ether derivatives of ethylene glycol;
- and dioxane.
A process for preparing tryptophol which comprises reducing a 3-indolyl compound selected from lower alkyl-, phenyl lower alkyl-, phenyl-and lower alkyl phenyl- 3-indolylglyoxylate and 3-indolylglyoxylyl halide using sodium or lithium borohydride in a solvent selected from ethanol, isopropanol or diglyme;
- the molar ratio of said borohydride to said 3-indolyl compound being in the range 3:1 to 2:1 and the reaction being carried out at a temperature between about 78.degree. C and about 100.degree. C.
Dependencies are inferred from the claim text.