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US 4,062,848 AGranted
Tetracyclic compounds
AssigneeAkzona Incorporated
InventorWillem Jacob van der Burg
Life of this patent
Estimating the term…
Abstract
The invention relates to compounds of the general formula I: ##STR1## or a salt thereof, in which A represents a pyridine ring or a halogen substituted pyridine ring, R.sub.1 represents hydrogen, alkyl (1-6 C), alkoxy (1-6 C), alkylthio (1-6 C), halogen, OH, SH or CF.sub.3 R.sub.2 represents hydrogen or a lower alkyl or aralkyl group and n and m may each be 1, 2 or 3 with the proviso that the sum of m and n must be 2, 3 or 4, having CNS activity, a pronounced antihistamine activity and little or no antiserotonin activity.
Claims4
A compound of the formula:
- ##STR10## an acid addition salt thereof of a pharmaceutically acceptable acid, or a pharmaceutically acceptable quaternary ammonium salt thereof, in which
- A represents pyridine or halogen-substituted pyridine,
- R.sub.1 respresent hydrogen, alkyl having 1 to 6 carbon atoms, alkoxy having 1 to 6 carbon atoms, alkylthio having 1 to 6 carbon atoms, halogen, OH, SH or CF.sub.3,
- R.sub.2 represents hydrogen, alkyl having 1 to 6 carbon atoms or phenylalkyl, the alkyl of which has 1 to 4 carbon atoms, and
- n and m represent the values 1, 2 or 3, with the proviso that the sum of n +m must be 2, 3 or 4.
2 more elements
The compound:
- ##STR12##
Dependencies are inferred from the claim text.