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US 4,062,847 AGranted
Process for preparing orotic acid
AssigneeDiamalt Aktiengesellschaft
InventorsPaul Rambacher, Siegfried Make
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Abstract
A method for the preparation of orotic acid and thioorotic acid is described which includes the formation of carboxymethylene-hydantoin or -thiohydantoin and subsequent rearrangement and isolation of orotic acid and thioorotic acid, respectively.
Claims6
A process for preparing a compound of the formula:
- ##STR2## which comprises reacting a compound of the formula:
- ##STR3## wherein R is hydrogen or an acyl group with glyoxylic acid in an alkaline medium to form a compound of the formula:
- ##STR4## wherein B is an inorganic or organic cation, resulting from the alkaline medium saponifying and ring closing said compound in an alkaline medium to form a compound of the formula:
- ##STR5## converting said compound in an alkaline medium to the salt of a compound of Formula IA, above, and recovering the free acid.
1 more element
Dependencies are inferred from the claim text.