Amino-substituted 1,2,3,4-tetrahydro-9H-tribenzo[b,d,f]azepines
AssigneeAkzona Incorporated
InventorWillem Jacob van der Burg
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Abstract
The invention discloses novel compounds of the general formula: ##STR1## and salts thereof, in which X stands for oxygen, sulphur, the group >NR.sub.7 or the group --CR.sub.8 R.sub.9 --; R.sub.1, r.sub.2, r.sub.3 and R.sub.4 represent hydrogen, hydroxy, halogen, alkyl (1-6 C), alkoxy (1-6 C), alkylthio (1-6 C) or trifluoromethyl; R.sub.5 and R.sub.6 represent hydrogen, alkyl (1-6 C), aralkyl (7-10 C) or together in combination with the nitrogen atom a heterocyclic five- or six-membered ring; R.sub.7 stands for hydrogen or alkyl (1-4 C); R.sub.8 and R.sub.9 stand for hydrogen or methyl, n is the number 0, 1 or 2 and The dotted line means an optional C--C bond, with valuable central nervous system (CNS) activities, especially antidepressant activity.
Claims25
A compound of the formula:
- ##STR18## or a pharmaceutically acceptable salt thereof, in which R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are selected from the group consisting of hydrogen, hydroxy, halogen, alkyl having 1 to 6 carbon atoms, alkoxy having 1 to 6 carbon atoms, alkylthio having 1 to 6 carbon atoms and trifluoromethyl,
- R.sub.5, r.sub.6 are selected from the group consisting of hydrogen, alkyl having 1 to 6 carbon atoms, aralkyl having 7 to 10 carbon atoms,
- R.sub.7 is selected from the group consisting of hydrogen and alkyl having 1 to 4 carbon atoms,
- n is selected from 0, 1 and 2, and
- the dotted line signifies an optional bond.
A compound of the formula:
- ##STR20## and the pharmaceutically acceptable salts thereof.
A compound of the formula:
- ##STR21## or a pharmaceutically acceptable salt thereof, in which R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are selected from the group consisting of hydrogen, hydroxy, halogen, methyl, methoxy and trifluoromethyl;
- R.sub.5 and R.sub.6 are selected from the group consisting of hydrogen, alkyl having 1 to 6 carbon atoms, and aralkyl having 7 to 10 carbon atoms;
- R.sub.4 is selected from the group consisting of hydrogen and alkyl having 1 to 4 carbon atoms;
- n is selected from 0, 1 and 2, and the dotted line signifies an optional bond.
2-Amino-9-methyl-1,2,3,4-tetrahydro-9H-tribenzo(b,d,f)-azepine.
2-Amino-7-chloro-9-methyl-1,2,3,4-tetrahydro-9H-tribenzo(b,d,f)-azepine.
2-Dimethylamino-7-methoxy-9-methyl-1,2,3,4-tetrahydro-9H-tribenzo(b,d,f) -azepine.
2-Methylamino-9-methyl-1,2,3,4-tetrahydro-9H-tribenzo(b,d,f)-azepine.
2-Benzylamino-9-methyl-1,2,3,4-tetrahydro-9H-tribenzo-(b,d,f)-azepine.
2-Dimethylamino-7-hydroxy-9-methyl-1,2,3,4-tetrahydro-9H-tribenzo(b,d,f )-azepine.
2-Dime thylamino-9,12-dimethyl-1,2,3,4-tetrahydro-9H-tribenzo(b,d,f)-azepine.
2-Dimethylamino-9-methyl-11-trifluormethyl-1,2,3,4-tetrahydro-9H-t ribenzo(b,d,f)-azepine.
2-Dimethylamino-11- trifluoromethyl-1,2,3,4-tetrahydro-9H-tribenzo(b,d,f)-azepine.
2-Dimethylamino-1,2,3,4-tetrahydro-9H-tribenzo(b,d,f)-azepine.
2-Dimethylaminoethyl-9-methyl-1,2,3,4-tetrahydro-9H-tribenzo(b ,d,f)-azepine.
2-Aminomethyl-9-methyl-1,2,3,4-tetrahydro-9H-tribenzo(b,d,f)-azepine.
2-Dimethylaminomethyl-9-methyl-1,2,3,4-tetrahydro-9H-tribenzo(b,d,f)-az epine.
2- Benzylaminomethyl-9-methyl-1,2,3,4-tetrahydro-9H-tribenzo(b,d,f)-azepine.
2-Aminomethyl-1,2,33,4-tetrahydro-9H-tribenzo(b,d,f)-azepine.
2-Amino-9-methyl-1,2,3,4,4a,13b-hexahydro-9H-tribenzo (b,d,f)-azepine.
2-Dimethylamino-9-methyl-1,2,3,4,4a,13b-hexhydro-9H-tribenzo(b,d,f)-aze pine.
2 -Dimethylamino-7-methoxy-9-methyl-1,2,3,4,4a,13b-hexahydro-9H-tribenzo(b,d, f)-azepine.
2-Amino methyl-9-methyl-1,2,3,4,4a,13b-hexahydro-9H-tribenzo(b,d,f)-azepine.
Dependencies are inferred from the claim text.