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US 4,062,815 AGranted
Resin peptides
AssigneeArmour Pharmaceutical Company
InventorsJohn Lawrence Hughes, Jay Kenneth Seyler, Robert Chung-Huang Liu
Life of this patent
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Abstract
Resin peptides useful in the preparation of salmon calcitonin are disclosed along with processes for preparing the same. The invention also embraces peptides from which the resin moiety has been cleaved and which are useful in the synthesis of salmon calcitonin together with processes for preparing the cleaved peptides. In general, the processes involve the solid phase synthesis procedures.
Claims2
A resin peptide having the structure:
- ##STR27## where X is divinylbenzene crosslinked polystyrene resin and BZ is benzyl, 4-methoxybenzyl, 3-4 dimethylbenzyl, 4-chlorobenzyl, 2-6 dichlorobenzyl, 4-nitrobenzyl, or benzhydryl.
A resin peptide having the structure:
- ##STR28## where X is divinylbenzene crosslinked polystyrene resin BZ is benzyl, 4-methylbenzyl, 3-4 dimethylbenzyl, 4-chlorobenzyl, 2-6 dichlorobenzyl, 4-nitrobenzyl, or benzhydryl, and T is nitro or tosyl.
Dependencies are inferred from the claim text.