Solid phase synthesis of protected peptides
AssigneeWisconsin Alumni Research Foundation
InventorsDaniel H. Rich, Sweet K. Gurwara
Life of this patent
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Abstract
The invention is addressed to the preparation of 3-nitro-4-bromomethyl benzoic acid, as a new compound from which 3-nitro-4-bromomethyl benzoyl amide polystyrene resin can be prepared for solid synthesis of protected peptide acids and amides and separation thereof without cleavage of acid labile protecting groups or decomposition of aromatic acid groups and from which purified polypeptides can be formed.
Claims4
The product having the general formula ##STR10## in which R is 0-8 carbon atoms in an alkyl or substituted alkyl group, X is NH, n is a number up to about 50 and the term amino acid denotes any one of the amino acids and peptides and mixtures thereof.
The method of producing the product having the general formula ##STR11## in which R is 0-8 carbon atoms in an alkyl or substituted alkyl group, X is 0, n is a number up to about 50, and the term amino acid denotes any one of the amino acids and peptides and mixtures thereof, comprising the step of reacting one or more protected amino acids or peptides with the compound having the general formula ##STR12##
Dependencies are inferred from the claim text.