Radio-assay of oestrogen
AssigneeThe Radiochemical Centre Limited
InventorsJohn Christopher Edwards, Paul Hemesley
Life of this patent
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Abstract
A method for the radio-assay of an oestrogen in a biological fluid which method comprises causing the oestrogen to compete with a radio-iodine derivative, selected from the group consisting of the 2-iodo-, 4-iodo- and 2,4-di-iodo- derivatives of the oestrogen, for reaction with a specific reagent for the oestrogen, separating the oestrogen and iodo-oestrogen bound to the specific reagent from the unbound oestrogen and iodo-oestrogen and measuring the radioactive concentration of one or both the bound and unbound fractions of oestrogen.
Claims9
A method for the radio-assay of an oestrogen in a biological fluid which method comprises
- a. causing said oestrogen to compete with a radio-iodine derivative, selected from the group consisting of the 2-iodo-, 4-iodo- and 2,4-di-iodo- derivatives of said oestrogen for reaction with a specific antibody to the oestrogen,
- b. separating the oestrogen and iodo-oestrogen bound to the specific antibody from the unbound oestrogen and iodo-oestrogen and
- c. measuring the radioactive concentration of one or both of the bound and unbound fractions of oestrogen.
Dependencies are inferred from the claim text.