Prostaglandin analogues
AssigneeOno Pharmaceutical Co., Ltd.
InventorsMasaki Hayashi, Tadao Tanouchi, Hiroyuki Ito, Isao Ohyama
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AssigneeOno Pharmaceutical Co., Ltd.
InventorsMasaki Hayashi, Tadao Tanouchi, Hiroyuki Ito, Isao Ohyama
Estimating the term…
Prostaglandin compounds of the formula: ##STR1## wherein A represents a grouping of formula II, III or IV indicated below and (i)R.sub.1 represents an unsubstituted n-butyl, n-pentyl, n-hexyl or n-heptyl radical, or such a radical carrying one, two or three alkyl substituents of 1 to 4 carbon atoms, or R.sub.1 represents a methyl, ethyl, propyl or butyl radical carrying a phenyl, cyclohexyl or cyclopentyl substituent, R.sub.2 represents a hydrogen atom or an alkyl radical of 1 to 4 carbon atoms, and R.sub.3 represents a hydrogen atom, or (ii) R.sub.1 represents n-butyl, or n-butyl or n-pentyl carrying one, two or three alkyl substituents of 1 to 4 carbon atoms, or R.sub.1 represents a methyl, ethyl, propyl or butyl radical carrying a phenyl, cyclohexyl or cyclopentyl substituent, R.sub.2 represents a hydrogen atom or an alkyl radical of 1 to 4 carbon atoms, and R.sub.3 represents an alkyl radical of 1 to 4 carbon atoms are disclosed. These compounds exhibit characteristic prostaglandin-like activity.
16(R)-Methyl-13,14-dihydro-PGE.sub.2.
The methyl ester of 16(R)-methyl-13,14-dihydro-PGE.sub.2.
The isobutyl ester of 16(R)-methyl-13,14-dihydro-PGE.sub.2.
The n-decyl ester of 16(R)-methyl-13,14-dihydro-PGE.sub.2.
16(.epsilon.)-Phenyl-.omega.-trinor-13,14-dihydro-PGE.sub.2.
16(.epsilon.)-Cyclohexyl-.omega.-trinor-13,14-dihydro-PGE.sub.2.
16(.epsilon.)-Cyclopentyl-.omega.-tetranor-13,14-dihydro-PGE.sub.2.
16(.epsilon.)-Cyclopentyl-.omega.-trinor-13,14-dihydro-PGE.sub.2.
Dependencies are inferred from the claim text.