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US 4,061,861 AGranted
7-[.alpha.-(2,3-DIHYDRO-2-OXO-1H-benzimidazol-1-ylcarbonyl-amino) arylacetamido]cephalosporins
AssigneeEli Lilly and Company
InventorWilliam H. W. Lunn
Life of this patent
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Abstract
Cephalosporin antibiotics of the formula ##STR1## in which, for example, R is phenyl, hydroxyphenyl, halophenyl, thienyl, or furyl; R.sub.1 is hydrogen, carbamoyloxy, acetoxy, a lower alkyl substituted 1H-tetrazol-5-ylthio or 1,3,4-thiadiazol-5-ylthio group; and R.sub.2 is hydrogen or methyl; are highly active broad spectrum antibiotics especially useful in the treatment of infections attributable to the gram-negative microorganisms.
Claims9
A compound of the formula ##STR25## in which R is phenyl, monohydroxyphenyl, dihydroxyphenyl, monohalophenyl, monohydroxy substituted monohalophenyl, thienyl, or furyl;
- R.sub.2 is hydrogen or methyl;
- and R.sub.5 is hydrogen, indanyl, phthalidyl, an acyloxymethyl group of the formula ##STR26## in which Y is C.sub.1 -C.sub.4 alkyl or phenyl, or, when R.sub.5 is hydrogen, the pharmaceutically acceptable non-toxic salts thereof.
Dependencies are inferred from the claim text.