Pyrimidin-6-yl acethydroxamic acids
AssigneeDelalande S.A.
InventorsClaude P. Fauran, Jeannine A. Eberle, Guy R. Bourgery, Guy R. Raynaud, Claude J. Gouret
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Abstract
Compounds of the formula ##STR1## IN WHICH R is aminocarbonylphenyl in which amino is --NH.sub.2, pyrrolidino, piperidino or morpholino, and Ar is phenyl substituted with chloro, fluoro, trifluoromethyl, methylenedioxy or one or more methoxy. The compounds are prepared by reacting 2-Ar-4-chloropyrimidin-6-yl ethylacetate with ##STR2## and then reacting that reaction product with hydroxylamine hydrochloride. The compounds possess vasodilatatory, anti-ulcerous, respiratory analeptic, hypotensive, diuretic, anti-depressive, analgesic, anti-inflammatory and neurotropic properties.
Claims6
A compound having the formula ##STR80## and Ar is phenyl substituted by one chloro, one fluoro, one trifluoromethyl, one methylenedioxy or one or more methoxy.
Dependencies are inferred from the claim text.