Anti-allergic oxanilate compounds
AssigneeThe Upjohn Company
InventorsCharles M. Hall, John B. Wright
Life of this patent
Estimating the term…
Abstract
A method of treating mammals for allergy and anaphylactic reactions of a reagin or non-reagin mediated nature which comprises administering prophylactically to said mammal an anti-allergy or anaphylactic reaction effective amount of a compound of the formula ##STR1## Novel compounds and compositions are also claimed.
Claims26
A pharmaceutical composition which comprises as the sole active ingredient an anti-asthma, allergic rhinitis, urticara, or food allergy effective amount of a compound of the formula ##STR16## wherein R is selected from the group consisting of hydrogen, a physiologically acceptable metal or amine cation, alkyl of one to six carbon atoms, inclusive, and ##STR17## wherein n is 0, 1 or 2;
- R.sub.1 and R.sub.2 are the same or different and are selected from the group consisting of hydrogen, halogen, nitro, cyano and ##STR18## with the proviso that when one or both of R.sub.1 and R.sub.2 are ##STR19## groups on a phenylene ring are not ortho to each other;
- and ##STR20## in association with a pharmaceutical carrier.
A pharmaceutical composition which comprises an anti-asthma, allergic rhinitis, urticaria or food allergy effective amount of a compound of the formula ##STR21## wherein R is selected from the group consisting of hydrogen, a physiologically acceptable metal or amine cation, alkyl of one to six carbon atoms, inclusive, and ##STR22## wherein n is 0, 1 or 2;
- R.sub.1 and R.sub.2 are the same or different and are selected from the group consisting of hydrogen, halogen, nitro, cyano and ##STR23## with the proviso that when one or both of R.sub.1 and R.sub.2 are ##STR24## groups on a phenylene ring are not ortho to each other;
- and ##STR25## in association with a pharmaceutical carrier suitable for inhalation.
A pharmaceutical composition which comprises an anti-asthma, allergic rhinitis, urticaria, or food allergy effective amount of a compound of the formula ##STR26## wherein R is selected from the group consisting of hydrogen and a physiologically acceptable metal or amine cation;
- R.sub.1 and R.sub.2 are the same or different and are selected from the group consisting of hydrogen, halogen, nitro, cyano and ##STR27## with the proviso that when one or both of R.sub.1 and R.sub.2 are ##STR28## , groups on a phenylene ring are not ortho to each other;
- and ##STR29## in association with a pharmaceutical carrier.
A method for treating a mammal for asthma, allergic rhinitis, urticaria or food allergy which comprises prophylactically adminstering to said mammal an anti-asthma, allergic rhinitis, urticara or food allergy effective amount of a compound of the formula ##STR30## wherein R is selected from the group consisting of hydrogen, a physiologically acceptable metal or amine cation, alkyl of one to six carbon atoms, inclusive, and ##STR31## wherein n is 0, 1 or 2;
- R.sub.1 and R.sub.2 are the same or different and are selected from the group consisting of hydrogen, halogen, nitro, cyano and ##STR32## with the proviso that when one or both of R.sub.1 and R.sub.2 are ##STR33## groups on a phenylene ring are not ortho to each other;
- and ##STR34## in association with a pharmaceutical carrier.
Dependencies are inferred from the claim text.