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US 4,061,778 AGranted
Iminodimethylene di-tert-alkylophenones and phenols
AssigneeSandoz Ltd.
InventorJeffrey Nadelson
Life of this patent
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Abstract
Substituted-iminodimethylene-di-tert-alkylophenones, e.g., 4",4"'-methyliminodimethylene-dipivalophenone, are prepared by treating a corresponding .alpha.-halo-p-tert-alkanoyl toluene with a substituted amine. The phenols are prepared from the corresponding phenones and both the phenones and the phenols are useful as hypolipidemic agents.
Claims7
A compound of the formula ##STR5## wherein R.sub.1 represents hydrogen, halo having an atomic weight of about 19 to 36 or straight chain lower alkoxy, and
- R.sub.2 and R.sub.3 each independently represent lower alkyl having 1 to 2 carbon atoms, and
- R.sub.4 represents lower alkyl having 1 to 4 carbon atoms,
- or a pharmaceutically acceptable acid addition salt thereof.
Dependencies are inferred from the claim text.