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US 4,061,777 AGranted
Vasodilatory terpeno-phenoxyalkylamines
AssigneeMar-Pha, Societe d'Etudeet d'Exploitation de Marques Mar-Pha
InventorJean Mardiguian
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AssigneeMar-Pha, Societe d'Etudeet d'Exploitation de Marques Mar-Pha
InventorJean Mardiguian
Estimating the term…
New terpeno-phenoxyalkylamines of the general formula: ##STR1## in which n is 0, 1 or 2, R.sub.1 is a hydrogen atom, a lower alkyl radical having a straight or branched chain with 1 to 4 carbon atoms, or an OH group, R.sub.2 and R.sub.3 each represent H, or a lower alkyl radical having a straight chain or branched chain with up to 4 carbon atoms, or a hydroxyethyl radical, R.sub.4 is a terpene radical selected from 2-isobornyl, 5-camphyl or 2-norbornyl of exo or endo configuration in the ortho, meta or para position with respect of the ether function R.sub.5 and R.sub.6 may each be H, a lower alkyl radical having a straight or branched chain with up to 4 carbon atoms or a halogen atom, As well as their physiologically acceptable non-toxic acid salts and their quaternary ammonium salts having antibacterial and cardiovascular vasodilatory properties.
A terpeno-phenoxyalkylamine of the general formula:
2-(2'-isobornyl-4',5'-dimethyl phenoxy) ethylamine in the form of a base of a physiologically acceptable non-toxic acid salt, or quaternary ammonium salt thereof.
2-(2'-isobornyl-4'-bromo-5'-methyl phenoxy) ethylamine in the form of a base or a physiologically acceptable non-toxic acid salt or quaternary ammonium salt thereof.
2-(2'-isobornyl-4'-bromo phenoxy) ethylamine in the form of a base or a physiologically acceptable non-toxic acid salt or quaternary ammonium salt thereof.
3-(2'-isobornyl-4',5'-dimethyl phenoxy) 1-amino propan-2-ol in the form of a base or a physiologically acceptable non-toxic acid salt or quaternary ammonium salt thereof.
3-(2'-isocamphyl-4',5'-dimethyl phenoxy) 1-amino propan 2-ol in the form of a base or a physiologically acceptable non-toxic acid salt or quaternary ammonium salt thereof.
3-(2'-isocamphyl-4',5'-dimethyl phenoxy) 1-isopropylamino propan 2-ol in the form of a base or a physiologically acceptable non-toxic acid salt or quaternary ammonium salt thereof.
N-hydroxyethyl 2-(2'-isobornyl-4',5'-dimethyl phenoxy) ethylamine in the form of a base or a physiologically acceptable non-toxic acid salt or quaternary ammonium salt thereof.
1-amino 3-(2'-isobornyl phenoxy) propan-2-ol in the form of a base of a physiologically acceptable non-toxic acid salt or quaternary ammonium salt thereof.
1-isopropyl amino 3-(2'-isobornyl phenoxy) propan-2-olin the form of a base of a physiologically acceptable non-toxic acid salt or quaternary ammonium salt thereof.
2-(2-isobornyl-4-chloro-5-methyl phenoxy) ethylamine in the form of a base or a physiologically acceptable non-toxic acid salt or quaternary ammonium salt thereof.
1-isopropylamino 3-(2'-isobornyl-4',5' dimethyl phenoxy propan-2-ol in the form of a base or a physiologically acceptable non-toxic acid salt or quaternary ammonium salt thereof.
1-Amino 3-(2-isocamphyl-4'-methyl phenoxy) propan-2-ol in the form of a base or a physiologically acceptable non-toxic acid salt or quaternary ammonium salt thereof.
1-isopropylamino 3-(2'-isocamphyl-4'-methyl phenoxy) propan-2-ol in the form of a base or a physiologically acceptable non-toxic acid salt or quaternary ammonium salt thereof.
1-isopropylamino 3-[2'-norbornyl-4',5'-dimethyl phenoxy] propan-2-ol in the form of a base or a physiologically acceptable non-toxic acid salt or quaternary ammonium salt thereof.
Dependencies are inferred from the claim text.