Halogenated amino methyl adamantane derivatives
AssigneeLilly Industries Limited
InventorsJiban Kumar Chakrabarti, Terrence Michael Hotten, David Edward Tupper
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Abstract
Novel 2-substituted-1-methylamino adamantanes of formula: ##STR1## where X is hydroxyl or halogeno, and R.sup.1, R.sup.2 and R.sup.3 are hydrogen or C.sub.1-4 alkyl or R.sup.2 and R.sup.3 together with the nitrogen form a heterocyclic ring, having anti-Parkinsonian activity, pharmaceutical formulations containing the active adamantanes and novel 4-protoadamantane spiro oxirane and 1,2-difunctionalized intermediates useful in the preparation of the final products of the invention.
Claims12
A compound of the formula ##STR8## wherein X represents a halogen atom, and wherein R.sup.2 and R.sup.3 are the same or different and represent hydrogen or a C.sub.1-4 alkyl group, at least one of R.sup.2 and R.sup.3 being C.sub.1-4 alkyl;
- or a pharmaceutically acceptable non-toxic acid addition salt thereof.
Dependencies are inferred from the claim text.