Polyhydroxyphenylchromanone salts and therapeutic composition
AssigneeDr. Madaus & Co.
InventorsRolf Hermann Heinrich Madaus, Gunter Halbach, Wilfried Trost
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Abstract
Salts of polyhydroxyphenylchromanones, e.g., silymarin or one or more members of the silymarin group, are reacted with a monoaminopolyhydroxy alcohol of the formula ##STR1## wherein X IS AN INTEGER FROM 3 TO 5; AND R.sub.1 and R.sub.2 are hydrogen, lower alkyl or hydroxyalkyl To give chemotherapeutic salt compounds which are water soluble while retaining a high degree of medical effectiveness. The salt compounds can be administered to mammals to antagonize or mitigate liver damage and inflammation.
Claims23
Therapeutic composition for the treatment of liver damage and inflammation comprising a salt of a Silymarin group polyhydroxyphenylchromanone with a pharmaceutically acceptable monoaminopolyhydroxy alcohol of the formula ##STR6## wherein x is an integer from 3 to 5;
- and
- R.sub.1 and R.sub.2 are hydrogen, lower alkyl or lower hydroxyalkyl and wherein said salt is present in therapeutically effective amounts.
Method of treating a subject suffering from liver damage or inflammation, which comprises administering to said subject in therapeutically effective amounts a salt of a Silymarin group polyhydroxyphenylchromanone with a pharmaceutically acceptable monoamino polyhydroxy alcohol of the formula. ##STR7## wherein X is an integer from 3 to 5;
- and R.sub.1 and R.sub.2 are hydrogen, lower alkyl or lower hydroxyalkyl.
Dependencies are inferred from the claim text.