Method for using 3-substituted-5-phenyl-5-pyridyl hydantoins as antiarrhythmic agents
AssigneeMiles Laboratories, Inc.
InventorsHerbert John Havera, Wallace Glenn Strycker
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Abstract
Compounds having the generic structure, ##STR1## and their nontoxic, pharmacologically acceptable salts are useful in the chemotherapy of arrhythmias in individuals for whom such therapy is indicated. In the preceding structural formula: R.sup.1 is a 2-pyridyl, 3-pyridyl, or 4-pyridyl radical; n is an integer of the set 1-3; and R.sup.2 is a hydrogen atom, a hydroxyl, or an equivalent alkoxyl group having from 1 to 3 carbon atoms.
Claims10
In a therapeutic method of treating a cardiac arrhythmia in an individual in whom such therapy is indicated by administration of an antiarrhytmic agent, the improvement comprising:
- administering to the individual an effective antiarrhythmic amount of a compound having the formula, ##STR15## or a pharmacologically acceptable, non-toxic salt thereof, in which:
- R.sup.1 is selected from the group consisting of 2-pyridyl, 3-pyridyl, or 4-pyridyl radicals;
- and
- R.sup.2 is selected from the group consisting of a hydrogen atom or a hydroxyl group.
Dependencies are inferred from the claim text.