Treating hypertension and central nervous system abnormalities
AssigneeJohn Wyeth & Brother Limited
InventorJohn Leheup Archibald
Life of this patent
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Abstract
A group of heterocyclic compounds generally exhibiting central nervous system activity (such as depressant and anti-convulsant activities) and, in some cases, cardiovascular and/or anti-inflammatory activity are described. The compounds have the formula ##STR1## where A is an ethyl or propyl group which is monosubstituted by defined substituents or a di(loweralkyl) amino (loweralkoxy) carbonyl group and R is a phenyl group which may be substituted by defined substituents. Pharmaceutical compositions having hypotensive activity or central nervous system activity comprise a non-toxic carrier and an effective amount of such a compound.
Claims3
A pharmaceutical composition having hypotensive activity or central nervous system activity comprising a carrier and an effective amount of a compound selected from those of the formula ##STR15## and their pharmaceutically acceptable acid addition salts, wherein A represents a member selected from the class consisting of
- i. alkyl containing 2 to 3 carbon atoms monosubstituted by a substituent selected from hydroxyl, di(lower alkyl) amino, cyano, halogen, groups of the formula -CO.NX.Y where X and Y are selected from hydrogen and lower alkyl, groups of the formula -CO.T where T is lower alkyl, the semicarbazone and phenylhydrazone derivatives of said groups of formula -CO.T, (Lower alkoxy) carbonyl and groups of the formula -N(CH.sub.2 R.sup.1)R.sup.2 where R.sup.1 is selected from phenyl, monohalophenyl, mono(lower alkyl) phenyl and mono (lower alkoxy) phenyl and R.sup.2 is pyridyl;
- and
- ii. di(lower alkyl) amino (lower alkoxy) carbonyl;
- and R represents a member selected from the class consisting of phenyl and phenyl substituted by one to two substituents selected from lower alkyl, halogen and nitro.
Dependencies are inferred from the claim text.