Imidazo[1,2-a]quinolines
AssigneeJohn Wyeth & Brother Limited
InventorRobin Michael Black
Life of this patent
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Abstract
The invention relates to imidazo[1,2-a]quinolines of formula (I) ##STR1## and their pharmaceutically acceptable acid addition salts. In formula I R.sup.1 and R.sup.2 which may be the same or different each represent hydrogen, lower alkyl, lower alkoxy, trifluoromethyl or halogen, R.sup.3 and R.sup.4 which may be the same or different each represent lower alkyl and R.sup.5 represents hydrogen, lower alkyl, aryl or arylloweralkyl. The compounds possess hypotensive activity.
Claims5
An imidazo[1,2-a]quinoline selected from the group consisting of compounds having the formula (I) ##STR8## and the pharmaceutically acceptable acid addition salts thereof, wherein R.sup.1 and R.sup.2 which may be the same or different each represent hydrogen, lower alkyl, lower alkoxy, trifluoromethyl or halogen, R.sup.3 and R.sup.4 which may be the same or different each represent lower alkyl and R.sup.5 represents hydrogen, lower alkyl, phenyl, phenyl substituted by R.sup.1 or phenylloweralkyl, with the proviso that R.sup.3 and R.sup.4 cannot be groups which give rise to steric hindrance.
A hypotensive composition comprising a hypotensively effective amount of an imidazol[1,2-a]quinoline selected from the group consisting of compounds having the formula (I) and the pharmaceutically acceptable acid addition salts thereof, wherein R.sup.1 and R.sup.2 which may be the same or different each represent hydrogen, lower alkyl, lower alkoxy, trifluoromethyl or halogen, R.sup.3 and R.sup.4 which may be the same or differnt each represent lower alkyl and R.sup.5 represents hydrogen, lower alkyl, phenyl, phenyl substituted by R.sup.1 or phenylloweralkyl, with the proviso that R.sup.3 and R.sup.4 cannot be groups which give rise to steric hindrance in association with a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.