Azeto [2,3-b][1,4] benzo diazepines
AssigneeDDSA Pharmaceuticals
InventorUmakant Devdas Shenoy
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Abstract
Novel aldehyde adducts of 1,4-benzodiazepines-4-oxides, novel azeto-[1,4]-benzodiazepine derivatives derived therefrom, acid addition salts thereof and methods for their preparation. The aldehyde adducts have the general formula I; the azeto-[1,4]-benzodiazepine derivatives have the general formula III. ##STR1##
Claims8
A compound of the formula ##STR7## wherein R.sup.1 represents hydrogen, chlorine, bromine, fluorine, iodine or nitro;
- R.sup.2 represents C.sub.1 -C.sub.10 alkyl;
- R.sup.3 represents lower alkyl group and R.sup.4 represents phenyl;
- or a pharmaceutically acceptable acid addition product thereof.
A therapeutic composition comprising at least one compound of the formula ##STR8## wherein R.sup.1 represents hydrogen, chlorine, bromine or nitro;
- R.sup.2 represents methyl or ethyl;
- R.sup.3 represents lower alkyl group and R.sup.4 represents phenyl, or a pharmaceutically acceptable acid addition salt thereof in an amount sufficient to provide a tranquilizing, sedative, or hypnotic effect in admixture with a pharmacologically acceptable diluent or carrier.
A process for the preparation of a compound according to claim 1 which comprises contacting a compound of the formula ##STR9## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 have the significance ascribed in claim 19 to R.sup.1, R.sup.2, R.sup.3 and R.sup.4, respectively, with an aqueous solution of a strong base.
6-chloro-2-ethyl-9-methyl-4-phenyl-9H-azeto-[2,3-b][1,4]-benzodiazepine.
6-chloro-9-methyl-4-phenyl-2-propyl-9H-azeto-[2,3-b][1,4]-benzodiazepine
The hydrochloride salt of 6-chloro-2-ethyl-4-phenyl-9-methyl-9H-azeto-[2,3-b][1,4]-benzodiazepine.
The hydrochloride salt of 6-chloro-9-methyl-4-phenyl-2-propyl-9H-azeto-[2,3-b][1,4]-benzodiazepine.
Dependencies are inferred from the claim text.