Stable preparation of water-soluble salts of dehydroepiandrosterone sulfate for parenteral administration
AssigneeKanebo, Ltd.
InventorsIsao Sugimoto, Yoko Sawase
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Abstract
A water-soluble salt of dehydroepiandrosterone sulfate is dissolved in an aqueous solution of a compound selected from the group consisting of dextran, macrogol, a neutral amino acid, a basic amino acid, an alkali metal salt of a weak acid, a solid amine, and mixtures thereof and then the resulting mixture is lyophilized. The product is stable on storage for a long period of time and easily soluble in water upon use for parenteral administration.
Claims13
A method for producing a stable pharmaceutical preparation for parenteral administration which comprises dissolving a water-soluble salt of dehydroepiandrosterone sulfate in an aqueous solution of a stabilizing agent selected from the group consisting of dextran, polyethylene glycol, a neutral or basic naturally occuring amino acid, an alkali metal salt of a weak acid, tris (hydroxymethy) amindethane and mixtures thereof, and lyphilizing the resulting mixture.
Dependencies are inferred from the claim text.