Method of therapeutically treating warm blooded animals and compositions therefor

A method of therapeutically treating a warm blooded animal having damaged or infected tissue which responds to treatment with an antibiotic comprising treating the warm blooded animal with a therapeutic composition containing an antibiotic in the presence of a catalyst and catalyst treated lignite,

• the said catalyst being prepared by a process comprising
• admixing a water soluble alkali metal silicate with an aqueous medium containing a dissolved substance which is a source of calcium ion and a dissolved substance which is a source of magnesium ion;
• the aqueous medium containing said dissolved substances in amounts to provide between about 1 .times. 10.sup.-4 and 1 .times. 10.sup.-1 mole per liter each of calcium ion and magnesium ion,
• the aqueous medium containing said dissolved substances in amounts to provide a molar ratio of calcium ion to magnesium ion between about 2.0:1.0 and 1.0:2.0,
• the alkali metal silicate having an alkali metal oxide to silicon dioxide ratio between about 0.9:1.0 and less than 2.0:1.0 and beng admixed with the aqueous medium in an amount of about 0.05-2 moles per liter,
• reacting the alkali metal silicate with said dissolved substances providing calcium ion and magnesium ion to produce an aqueous suspension of finely divided particles of the reaction product,
• admixing a micelle-forming surfactant with the aqueous medium in an amount to form catalyst micelles comprising said finely divided particles of the present product upon agitating the aqueous medium, and
• agitating the aqueous medium containing the finely divided particles of the reaction product and surfactant to form said catalyst micelles;
• and
• the said catalyst treated lignite being prepared by a process comprising intimately contacting solid lignite in particulate form with a liquid aqueous medium containing a catalytically effective amount of the said catalyst,
• the said particles of the lignite having active sites therein which react with at least one component of the said aqueous medium containing the catalytically effective amount of the catalyst under liquid phase conditions and in the presence of the said catalyst, and
• the said particles of the lignite being intimately contacted under liquid phase conditions until the active sites thereof react with at least one component of the said aqueous medium containing the catalytically effective amount of the catalyst and until the lignite is soluble in an aqueous medium.

A method of treating infected and damaged tissue and relieving stress and shock in warm blooded animals comprising administering thereto a therapeutically effective amount of a catalyst and a therapeutically effective amount of catalyst treated lignite,

• the said catalyst being prepared by a process comprising
• admixing a water soluble alkali metal silicate with an aqueous medium containing a dissolved substance which is a source of calcium ion and a dissolved substance which is a source of magnesium ion;
• the aqueous medium containing said dissolved substances in amounts to provide between about 1 .times. 10.sup.-4 and 1 .times. 10.sup.-1 mole per liter each of calcium ion and magnesium ion,
• the aqueous medium containing said dissolved substances in amounts to provide a molar ratio of calcium ion to magnesium ion between about 2.0:1.0 and 1.0:2.0,
• the alkali metal silicate having an alkali metal oxide to silicon dioxide ratio between about 0.9:1.0 and less than 2.0:1.0 and being admixed with the aqueous medium in an amount of about 0.05-2 mole per liter.
• reacting the alkali metal silicate with said dissolved substances providing calcium ion and magnesium ion to produce an aqueous suspension of finely divided particles of the reaction product,
• admixing a micelle-forming surfactant with the aqueous medium in an amount to form catalyst micelles comprising said finely divided particles of the reaction product upon agitating the aqueous medium, and
• agitating the aqueous medium containing the finely divided particles of the reaction product and surfactant to form said catalyst micelles;
• and
• the said catalyst treated lignite being prepared by a process comprising intimately contacting solid lignite in particulate form with a liquid aqueous medium containing a catalytically effective amount of the said catalyst,
• the said particles of the lignite having active sites therein which react with at least one component of the said aqueous medium containing the catalytically effective amount of the catalyst under liquid phase conditions and in the presence of the said catalyst, and the said the said particles of the liqnite being intimately contacted under liquid phase conditions until the active sites thereof react with at least one component of the said aqueous medium containing the catalytically effective amount of the catalyst and until the lignite is soluble in an aqueous medium.