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US 4,061,729 AGranted
Prostanoic acid derivatives and therapeutic compositions
AssigneeRoussel Uclaf
InventorsJacques Martel, Jean Buendia, Michel Vivat
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AssigneeRoussel Uclaf
InventorsJacques Martel, Jean Buendia, Michel Vivat
Estimating the term…
Novel prostanoic acid derivatives of the formula ##STR1## wherein R is hydrogen or alkyl having 1 to 4 carbon atoms, m is a whole number from 3, 4 or 5, n is a whole number from 2, 3 or 4, R' is either a linear or branched, saturated or unsaturated aliphatic hydrocarbon having 1 to 4 carbon atoms, or a saturated or mono unsaturated cyclohydrocarbon having 3 to 6 carbon atoms and A is either alkoxy having 1 to 4 carbon atoms or oxygen of a ketonic group, the dotted lines in the pentagonal ring are possible positions of a single double bond where, when A is a ketonic oxygen, the double bond is on the exterior of the ring and when A is alkoxy, the double bond is in one of the two interior positions of the ring, as well as the pharmaceutically compatible salts of mineral or organic bases when R is hydrogen in their .alpha.,.beta. or .beta.,.alpha. forms and mixtures thereof; as well as the process for their preparation, and the therapeutic compositions containing them.
A compound of the formula ##STR24## wherein R is a member selected from the group consisting of H, lower alkyl having 1 to 4 carbon atoms and acid salts of pharmaceutically compatible bases, m is an integer 3,4 or 5, n is an integer 2,3 or 4, R' is a member selected from the group consisting of alkenyl of 2 to 4 carbon atoms and cycloalkenyl of 3 to 6 carbon atoms, A is a member selected from the group consisting of ketonic oxygen and alkoxy of 1 to 4 carbon atoms, one of a or b being double bond when A is alkoxy, the dotted line to A being a double bond when A is a ketonic oxygen, and the wavy lines represent a paired configuration selected from the group consisting of .alpha.,.beta. and .beta.,.alpha. and mixtures thereof.
The 15SR and 15RS isomers of methyl (8RS, 12RS, 15.xi.)-(5Z, 13E)-15-hydroxy-9-oxo-15-vinyl-5,13-prostadienoate.
An antibronchoconstrictive composition comprising an effective amount of at least one compound of the formula ##STR25## wherein R is a member selected from the group consisting of H, lower alkyl having 1 to 4 carbon atoms and acid salts of pharmaceutically compatible bases, m is an integer 3,4 or 5, n is an integer 2,3 or 4, R' is a member selected from the group consisting of alkenyl of 2 to 4 carbon atoms and cycloalkenyl of 3 to 6 carbon atoms, A is a member selected from the group consisting of ketonic oxygen and alkoxy of 1 to 4 carbon atoms, one of a or b being a double bond when A is alkoxy, the dotted line to A being a double bond when A is a ketonic oxygen, and the wavy lines represent a paired configuration selected from the group consisting of .alpha.,.beta. and .beta.,.alpha. and mixture thereof and a major amount of a pharmaceutical carrier.
An hypotensive composition comprising an hypotensively effective amount of at least one compound of the formula ##STR26## wherein R is a member selected from the group consisting of H, lower alkyl having 1 to 4 carbon atoms and acid salts of pharmaceutically compatible bases, m is an integer 3,4 or 5, n is an integer 2,3 or 4, R' is a member selected from the group consisting of alkenyl of 2 to 4 carbon atoms and cycloalkenyl of 3 to 6 carbon atoms, A is a member selected from the group consisting of ketonic oxygen and alkoxy of 1 to 4
A compound of claim 20 of the formula ##STR27## wherein R is hydrogen, lower alkyl of 1 to 4 carbon atoms or salts of pharmaceutically acceptable bases, m is from 3 to 5 and n is from 2 to 4.
Dependencies are inferred from the claim text.