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US 4,061,670 AGranted
15-Deoxy-16-hydroxy-16-vinyl and cyclopropyl substituted prostanoic acids and congeners
AssigneeAmerican Cyanamid Company
InventorsMiddleton Brawner Floyd, Jr., Martin Joseph Weiss, Charles Vincent Grudzinskas, Sow-Mei Lai Chen
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Abstract
This disclosure describes novel 15-deoxy-16-hydroxy-16-substituted prostanoic acids and congeners thereof having utility as bronchodilators as hypotensive agents, and as agents for the control of excessive gastric secretion.
Claims13
An optically active compound of the formula:
- ##STR25## or a racemic mixture of that formula and the mirror image thereof wherein R.sub.1 is selected from the group consisting of hydrogen and alkyl having from 1 to 12 carbon atoms;
- R.sub.2 is selected from the group consisting of alkyl having from 3 to 7 carbon atoms;
- R.sub.3 is hydroxy;
- Y is a divalent moiety of the formulae:
- ##STR26## X is a divalent moiety selected from the group consisting of those of the formulae:
- ##STR27## wherein R.sub.5 is selected from the group consisting of vinyl and cyclopropyl;
- Z is a divalent moiety of the formulae:
- ##STR28## wherein n is an integer from 3 to 5, inclusive;
- the moiety -C.sub.13 -C.sub.14 -is trans-vinylene;
- and the pharmacologically acceptable cationic salts thereof when R.sub.1 is hydrogen.
7 more elements
Dependencies are inferred from the claim text.