Process for the preparation of 2-(4-isobutylphenyl)-propiohydroxamic acid
AssigneeSocieta Italo-Britannica L. Manetti-H. Roberts & C.
InventorsGiovanni Orzalesi, Renato Selleri
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Abstract
2-(4-Isobutylphenyl)-propiohydroxamic acid is prepared by mixing anhydrous methanol with 2-(4-isobutylphenyl)-propionitrile, saturating the mixture with dry hydrogen chloride, reacting, diluting the reaction product with ethyl ether, reacting the precipitate with hydroxylamine hydrochloride in methanol and with 50% NaOH, stirring, diluting with water and precipitating with carbon dioxide.
Claims1
A process for the preparation of 2-(4isobutylphenyl)-propiohydroxamic acid comprising the steps of forming a mixture of 2-(4-isobutylphenyl)-propionitrile as a starting compound and anhydrous methanol, saturating said mixture with dry hydrochloric gas under cooling, reacting and then diluting the reaction product by ethyl ether, whereby a precipitate is formed, reacting the precipitate with a mixture of a methanol solution of hydroxylamine hydrochloride and a sodium hydroxide solution under stirring, diluting the reaction product with water and precipitating the desired compound by carbon dioxide.
Dependencies are inferred from the claim text.