Back to results
US 4,061,665 AGranted
5,6-Didehydro-.omega.-phenoxy-PGE.sub.2.alpha. analogs
AssigneeThe Upjohn Company
InventorChiu-Hong Lin
Life of this patent
Estimating the term…
Abstract
This invention comprises certain analogs of the prostaglandins in which there is a triple bond between C-5 and C-6 or C-4 and C-5. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.
Claims24
A prostaglandin analog of the formula ##STR1## WHEREIN G IS ONE, 2, OR 3;
- WHEREIN Y is trans--CH.dbd.CH--;
- wherein M.sub.1 is
- R.sub.5 OH
- or
- R.sub.5 OH,
- wherein R.sub.5 is hydrogen or methyl;
- Wherein T is chloro, fluoro, trifluoromethyl, alkyl of one to 3 carbon atoms, inclusive, or alkoxy of one to 3 carbon atoms, inclusive, and s is zero, one, 2, or 3, the various T's being the same or different, with the proviso that not more than two T's are other than alkyl;
- Wherein L.sub.1 is
- R.sub.3 R.sub.4,
- r.sub.3 r.sub.4,
- or a mixture of
- R.sub.3 R.sub.4
- and
- R.sub.3 R.sub.4,
- wherein R.sub.3 and R.sub.4 are hydrogen or methyl being the same or different;
- and
- WHEREIN R.sub.1 is hydrogen, alkyl of one to 12 carbon atoms, inclusive, cycloalkyl of 3 to 10 carbon atoms, inclusive, aralkyl of 7 to 12 carbon atoms, inclusive, phenyl, phenyl substituted with one, two or three chloro or alkyl of one to 3 carbon atoms, inclusive, or a pharmacologically acceptable cation.
14 more elements
Dependencies are inferred from the claim text.