Thiazolidine derivatives
AssigneeHoechst Aktiengesellschaft
InventorsHans-Jochen Lang, Roman Muschaweck
Life of this patent
Estimating the term…
Abstract
The invention relates to thiazolidine derivatives having in 4-position a hydroxy group and a 3'-sulphamyl-phenyl substituent the phenyl ring of which is di-substituted by halogen or methyl, in 2 position an imino group and in 1-position an aliphatic or cycloaliphatic substituent. Said thiazolidines have diuretic activity. The invention also relates to a process for the manufacture of said compounds.
Claims7
Thiazolidine derivatives of the general formula I ##STR64## in which R.sup.1 represents alkyl or alkenyl radicals of 1 to 4 carbon atoms, cycloalkyl groups of 3 to 6 carbon atoms, R.sup.2 represents an alkyl or alkenyl group of 1 to 6 carbon atoms which may be substituted by alkoxy groups of 1 to 2 carbon atoms, cycloalkyl groups of 3 to 8 carbon atoms, phenylalkyl groups of 1 to 2 carbon atoms in the alkyl moiety, and in which R.sup.1 and R.sup.2 together may represent an alkylene chain of 2 to 4 carbon atoms which may be branched, Y represents chlorine, bromine or methyl and R.sup.3 and R.sup.4 represent hydrogen, chlorine, bromine or methyl, the two radicals R.sup.3 and R.sup.4 representing at the same time neither hydrogen, nor chlorine, bromine or methyl, R.sup.5 and R.sup.6 represent hydrogen or lower alkyl of 1 to 4 carbon atoms, R.sup.6 may additionally represent a phenylalkyl group, and their acid addition salts with physiologically tolerated acids.
Dependencies are inferred from the claim text.