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US 4,061,643 AGranted
Certain 16-aryloxy-11,12-seco-prostaglandins
AssigneeMerck & Co., Inc.
InventorsEdward J. Cragoe, Jr., John B. Bicking
Life of this patent
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Abstract
This invention relates to aryloxy-, alkoxy-, arylthio-, and alkylthio-11,12-seco-prostaglandins and to processes for their manufacture. These compounds have prostaglandin-like activity and are particularly useful in fertility control such as for estrus synchronization in animals and postcoital contraceptive agents in humans.
Claims10
The compound of the formula ##STR23## wherein R is selected from the group consisting of carboxy and a carboxy salt, and alkoxycarbonyl (--COOAlk) wherein Alk is alkyl having 1-10 carbon atoms;
- R.sup.1 is selected from the group consisting of acetyl, propionyl, 1-hydroxyethyl, 1-hydroxypropyl and hydroxymethyl;
- R.sup.2 is hydrogen or lower alkanoyl;
- R.sup.3 is O--R.sup.6 or wherein R.sup.6 is
- pyridyl, pyrimidinyl, furfuryl, or thenyl;
- A is methylene (--CH.sub.2 --);
- Y is selected from the group consisting of ethylene, vinylene, or ethynylene;
- and
- Z is selected from the group consisting of ethylene, vinylene or ethynylene.
5 more elements
Dependencies are inferred from the claim text.