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US 4,061,637 AGranted
Certain 4-aryl-5-(4-phenylpiperazino)alkyl-4-thiazolin-2-ones
AssigneeIstituto Luso Farmaco D'Italia S.p.A.
InventorsElso Manghisi, Giuseppe Cascio, Giancarlo Fregnan
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Abstract
The invention provides novel 4-aryl-5-aminoalkyl-4-thiazolin-2-ones and their salts and complexes which have activity on the central nervous system, the cardio-vascular system, and anti-inflammatory, adrenolytic and anti-ulcer activity.
Claims9
4-Aryl-5-aminoalkyl-4-thiazoline-2-ones of the formula:
- ##STR10## and their pharmaceutically acceptable salts, in which Ar represents phenyl, lower alkylphenyl, trifluoromethylphenyl, lower alkoxyphenyl, lower dialkylaminophenyl, halogen phenyl or lower alkylmercaptophenyl;
- Alk represents a saturated or unsaturated, linear or branched chain of 1 to 3 carbon atoms;
- ##STR11## is a piperazine-4 subsituted by phenyl;
- Z represents an oxygen or sulfur atom;
- and R.sub.3 represents a hydrogen atom or methyl, acetyl, benzoyl or methylaminocarbonyl.
2 more elements
Dependencies are inferred from the claim text.