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US 4,061,630 AGranted
7-Substituted-ureido-3-carbamoyloxymethyl cephalosporin antibiotics
AssigneeEli Lilly and Company
InventorDavid K. Herron
Life of this patent
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Abstract
Cephalosporin compounds represented by the formula ##STR1## wherein R is an acylamino group ##STR2## and R' is for example phenyl or furyl, R" is H or CH.sub.3 ; or R is a substituted ureido group ##STR3## and R" is H or CH.sub.3, R"' is e.g., C.sub.1 -C.sub.3 alkyl; or R is a cyclic ureido group, e.g., imidazolidine-2-one-1-yl and wherein R.sub.1 is phenyl, substituted phenyl, thienyl, or furyl; are broad spectrum antibiotics exhibiting an expanded spectrum of activity vs. gram-negative microorganisms.
Claims8
A compound of the formula ##STR44## wherein R" is hydrogen or methyl;
- R"' is hydrogen, C.sub.1 -C.sub.2 alkyl, allyl, phenyl, benzyl, or furfuryl;
- R.sub.1 is 2-thienyl, 2-furyl, phenyl, or phenyl substituted by C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, halogen, hydroxy, or nitro;
- R.sub.2 is hydrogen or C.sub.1 -C.sub.3 alkyl;
- and the pharmaceutically acceptable non-toxic salts thereof.
1 more element
Dependencies are inferred from the claim text.