7-{3-Hydroxy-2-[4-hydroxy-4-(lower alkyl)-trans-1-octen-1-yl]-5-oxocyclopent-1-yl}heptanoic acids and esters
AssigneeG. D. Searle & Co.
InventorsPaul W. Collins, Raphael Pappo
Life of this patent
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Abstract
7-{3-Hydroxy-2-[4-hydroxy-4-(lower alkyl)-trans-1-octen-1-yl]-5-oxocyclopent-1-yl{heptanoic acids and esters, displaying valuable pharmacological properties, e.g., gastric anti-secretory, are produced by the reaction of a 7-(3-oxygenated-5-oxocyclopent-1-en-1-yl)heptanoic acid or ester with the appropriate organometallic reagent.
Claims5
A compound of the formula
- wherein R.sub.1 is hydrogen or lower alkyl;
- R.sub.2 and R.sub.3 are hydrogen or a lower alkanoyl, tetrahydropyran-2-yl, or tri(lower
The compound which is racemic methyl 7-[(3(R)-hydroxy-2.beta.-(4(S)-4-hydroxy-4-methyl-trans-1-octen-1-yl)-5-ox ocyclopent-1.alpha.-yl]heptanoate.
The compound which is methyl 7-[(3(R)-hydroxy-2.beta.-(4(RS)-4-hydroxy-4-methyl-trans-1-octen-1-yl)-5-o xocyclopent-1.alpha.-yl]heptanoate.
Dependencies are inferred from the claim text.