Anthranilic acid amides
AssigneeSandoz Ltd.
InventorPaul L. Anderson
Life of this patent
Estimating the term…
Abstract
Derivatives of trifluoromethyl-substituted anthranilic acid amides, e.g., N-methyl-o-amino-.alpha.,.alpha.,.alpha.-trifluoromethyl-p-toluamide, are useful as minor tranquilizers and muscle relaxants.
Claims17
A compound which is a free base of the formula ##STR11## in which R is a hydrogen atom, or alkanoyl having from 2 to 4 carbon atoms;
- R.sup.1 is a hydrogen atom or alkyl having from 1 to 6 carbon atoms;
- and
- R.sup.2 is alkyl having from 1 to 6 carbon atoms or hydroxy-alkyl having from 1 to 6 carbon atoms, the hydroxy function being located at a carbon atom other than the carbon atom adjacent to the nitrogen atom;
- provided that when R is alkanoyl then R.sup.2 is alkyl;
- or a non toxic pharmaceutically acceptable acid addition salt thereof when R is a hydrogen atom.
A pharmaceutical composition which is useful as a minor tranquilizer in a mammal comprising from about 35 to 750 milligrams of a compound which is a free base of the formula ##STR12## in which R is a hydrogen atom, or alkanoyl having from 2 to 4 carbon atoms;
- R.sup.1 is a hydrogen atom or alkyl having from 1 to 6 carbon atoms;
- and
- R.sup.2 is alkyl having from 1 to 6 carbon atoms or hydroxy-alkyl having from 1 to 6 carbon atoms, the hydroxy function being located at a carbon atom other than the carbon atom adjacent to the nitrogen atom;
- provided that when R is alkanoyl then R.sup.2 is alkyl;
- or a non-toxic pharmaceutically acceptable acid addition salt thereof when R is a hydrogen atom, and a pharmaceutically acceptable carrier.
A method of treating anxiety in a mammal in need of such treatment which comprises internally administering an amount of a compound which is a free base of the formula ##STR13## in which R is a hydrogen atom, or alkanoyl having from 2 to 4 carbon atoms;
- R.sup.1 is a hydrogen atom or alkyl having from 1 to 6 carbon atoms;
- and
- R.sup.2 is alkyl having from 1 to 6 carbon atoms or hydroxy-alkyl having from 1 to 6 carbon atoms, the hydroxy function being located at a carbon atom other than the carbon atom adjacent to the nitrogen atom;
- provided that when R is alkanoyl then R.sup.2 is alkyl;
- or a non-toxic pharmaceutically acceptable acid addition salt thereof when R is a hydrogen atom, effective in relieving anxiety in said mammal.
Dependencies are inferred from the claim text.