Amidinoureas for treating diarrhea
AssigneeWilliam H. Rorer, Inc.
InventorsJulius Diamond, George H. Douglas
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Abstract
A new class of chemical compounds and their process of preparation is described. These compounds have valuable properties as anti-diarrheal agents.
Claims22
A method for the treatment of diarrhea in humans and mammals which comprises the administering thereto between 0.01 to 500 mg/kg per day of a compound of the formula:
- ##STR8## where:
- R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 may be the same or different and are:
- hydrogen,
- halo,
- loweralkyl,
- trifluoromethyl,
- nitro,
- methoxy, ethoxy
- hydroxy,
- benzyloxy
- acetyloxy,
- cyano,
- trifluoromethoxy or
- methylsulfonyl
- R and R.sub.n are hydrogen or
- loweralkyl;
- R' and R" are hydrogen,
- alkyl,
- cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl,
- benzyl or phenethyl;
- and
- the non-toxic acid addition salts thereof.
A method for the treatment of diarrhea in humans and mammals which comprises the administering thereto between 0.01 to 500 mg/kg per day of a compound of the formula:
- ##STR9## where substitution of R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are selected from the group consisting of:
- R.sub.2 is loweralkyl;
- R.sub.2 and R.sub.6 are loweralkyl;
- R.sub.2 is loweralkyl and R.sub.6 is methoxy or ethoxy;
- R.sub.2 is loweralkyl and R.sub.6 is halo;
- R.sub.2 is loweralkyl and R.sub.6 is nitro;
- R.sub.2, r.sub.4 and R.sub.6 are loweralkyl;
- and
- R.sub.2 is loweralkyl and R.sub.4 and R.sub.6 are halo;
- all other members of R.sub.2, R.sub.3, R.sub.4, R.sub.5, and R.sub.6 being hydrogen;
- R is hydrogen or loweralkyl;
- R' and R" are hydrogen,
- alkyl,
- cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl,
- benzyl or phenethyl;
- R.sub.n is hydrogen or loweralkyl provided at least one of R, R' and R" is other than hydrogen;
- and
- the non-toxic acid addition salts thereof.
A method for the treatment of diarrhea in humans and mammals which comprises the administering thereto between 0.01 and 500 mg/kg per day of a compound of the formula:
- ##STR10## where substitution of R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are selected from the group consisting of:
- R.sub.3 and R.sub.4 are hydroxy, methoxy or ethoxy;
- R.sub.3, r.sub.4 and R.sub.5 are hydroxy, methoxy or ethoxy;
- R.sub.2 and R.sub.5 are dihalo;
- and
- R.sub.2 and R.sub.6 are dihalo;
- all other members of R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 being hydrogen;
- R is hydrogen or loweralkyl;
- R' and R" are hydrogen,
- alkyl,
- cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl,
- benzyl or phenethyl;
- R.sub.n is hydrogen or loweralkyl provided at least one of R, R' and R" is other than hydrogen;
- and
- the non-toxic acid addition salts thereof.
Dependencies are inferred from the claim text.