Indole-carboxylic carbon compounds and pharmaceutical compositions containing them
AssigneeBoehringer Mannheim GmbH
InventorsVladimir Hrstka, Manfred Hubner, Manfred Kuhr, Felix Helmut Schmidt, Walter Aumuller
Life of this patent
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Abstract
Indole-carboxylic acid compounds of the formula: ##STR1## wherein R.sub.1 is lower alkyl or alkoxy radical or halogen; R.sub.2 is halogen; lower alkyl or alkoxy radical; or R.sub.1 and R.sub.2 can together also form an alkylene bridge containing 3 to 5 carbon atoms, which can optionally contain one or more double bonds; and, but less preferably, when R.sub.1 is a lower alkyl or alkoxy radical, R.sub.2 can also be a hydrogen atom, and physiologically compatible salts and esters thereof, Are outstandingly effective as blood sugar-lowering agents.
Claims10
A compound selected from
- 4-methoxy-5-methylindole-2-carboxylic acid,
- 5-methoxy-4-methylindole-2-carboxylic acid, and the pharmaceutically acceptable salts and lower alkyl esters thereof.
4-Methoxy-5-methylindole-2-carboxylic acid.
5-Methoxy-4-methyl-indol-2-carboxylic acid.
Ethyl-5-methoxy-4-methyl-indol-2-carboxylate.
Method of depressing the blood sugar level in a subject which method comprises administrating to said subject an anti-diabetically effective amount of a compound selected from
- 4-methoxy-5-methylindole-2-carboxylic acid,
- 5-methoxy-4-methylindole-2-carboxylic acid, and the pharmaceutically acceptable salts and lower alkyl esters thereof.
Dependencies are inferred from the claim text.