(+) AND (-) 1-Methyl-4-(3-cyano-5H-dibenzo(a,d)-cyclohepten-5-ylidene)piperidine containing compositions and methods for using same
AssigneeMerck & Co., Inc.
InventorDavid C. Remy
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Abstract
Resolution of 1-methyl-4-(3-cyano-5H-dibenzo-[a,d]-cyclohepten-5-ylidene)piperidine provides a levorotary isomer (-) having major tranquilizer pharmaceutical utility and a dextrorotary isomer (+) having anticholinergic pharmaceutical utility. Also disclosed are pharmaceutical compositions comprising either isomer substantially free of the other; pharmaceutical compositions comprising preferred ratios of the (+) and (-) isomers; and methods of treatment comprising administering such compounds and compositions.
Claims4
A method of producing a tranquilizing effect comprising administering to a patient in need of such treatment a therapeutically effective amount of (-) 1-methyl-4-(3-cyano-5H-dibenzo[a,d]-cyclohepten-5-ylidene)-piperidine substantially free of the corresponding dextrorotary isomer or a nontoxic pharmaceutically acceptable acid addition salt thereof.
A method of producing an anticholinergic effect comprising administering to a patient in need of such treatment a therapeutically effective amount of (+) 1-methyl-4-(3-cyano-5H-dibenzo[a,d]-cyclohepten-5-ylidene)-piperidine substantially free of the corresponding levorotary isomer or a nontoxic pharmaceutically acceptable acid addition salt thereof.
A pharmaceutical composition in unit dosage form comprising a therapeutically effective amount of (-) 1-methyl-4-(3-cyano-5H-dibenzo[a,d]-cyclohepten-5-ylidene)-piperidine substantially free of the corresponding dextrorotary isomer or a nontoxic pharmaceutical acid addition salt thereof and a pharmaceutical carrier therefor.
A pharmaceutical composition in unit dosage form comprising a therapeutically effective amount of (+) 1-methyl-4-(3-cyano-5H-dibenzo[a,d]-cyclohepten-5-ylidene)-piperidine substantially free of the corresponding levorotary isomer or a nontoxic pharmaceutical acid addition salt thereof and a pharmaceutical carrier therefor.
Dependencies are inferred from the claim text.