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US 4,060,621 AGranted
Pyridyl alkylguanidine compounds
AssigneeSmith Kline & French Laboratories Limited
InventorsGraham John Durant, John Colin Emmett, Charon Robin Ganellin
Life of this patent
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Abstract
The compounds are pyridyl alkylguanidines, fo example N-benzenesulphonyl-N'-methyl-N"-[2-((3-hydroxy-2-pyridyl)methylthio)ethyl] guanidine, which are inhibitors of histamine activity.
Claims9
A compound of the formula:
- ##STR6## wherein R.sub.1 is hydrogen or lower alkyl;
- R.sub.2 is a grouping of the formula:
- Het -- (CH.sub.2).sub.m Z(CH.sub.2).sub.n --
- wherein Het is a pyridyl ring which is optionally substituted by lower alkyl, trifluoromethyl, hydroxy, halogen or amino;
- Z is sulphur, oxygen, NH or a methylene group;
- m is 0, 1 or 2 and n is 2 or 3, the sum of m and n being from 2 to 4;
- X is COR.sub.3, CSR.sub.3, SO.sub.2 R.sub.4 or nitro;
- R.sub.3 is lower alkyl, lower alkoxy, or amino;
- and R.sub.4 is lower alkyl, trifluoromethyl or amino or a pharmaceutically acceptable acid addition salt of said compound, provided that X is nitro only when Z is methylene and R.sub.3 is amino only when Z is sulphur, oxygen or NH.
6 more elements
Dependencies are inferred from the claim text.