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US 4,060,613 AGranted
3-Aryloxy-2(4-loweralkyl-1-piperazinyl)propanols, their alkylethers, and use thereof
AssigneeAyerst McKenna and Harrison Ltd.
InventorsJean-Marie Ferland, Real Laliberte, Wilbur Lippmann, Thomas A. Pugsley
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Abstract
Disclosed herein are compounds of the formula ##STR1## in which Ar is phenyl or 1-naphthyl; R.sup.1 is hydrogen or lower alkyl; and R.sup.2 and R.sup.3 together with the nitrogen atom to which they are joined form a hyterocyclic amine radical selected from the group consisting of 1-pyrrolidinyl, piperidino, morpholino and 4-(lower alkyl)-1-piperazinyl. The compounds are antidepressant agents and methods for their preparation and use also are disclosed.
Claims5
A compound of formula 1 ##STR4## in which Ar is phenyl or 1-naphthyl;
- R.sup.1 is hydrogen or lower alkyl having from one to six carbon atoms in a straight chain and three to four carbon atoms in a branched chain;
- and R.sup.2 and R.sup.3 together with the nitrogen atom to which they are joined form a heterocyclic amine radical consisting of 4-(lower alkyl)-1-piperazinyl;
- or a therapeutically acceptable acid addition salt thereof.
Dependencies are inferred from the claim text.