Substituted hydroxymethyl benzodiazepines

A benzodiazepine derivative of the formula I ##STR3## in which R.sub.1 represents a radical selected from the group consisting of hydrogen and halogen atoms and trifluoromethyl, cyano, nitro, lower alkyl, lower alkoxy and lower alkylthio:

• R.sub.2 represents a radical selected from the group consisting of hydrogen atoms and hydroxy, lower alkyl, lower alkoxy and lower alkanoyloxy:
• R.sub.3 represents a radical selected from the group consisting of lower alkyl, hydroxy (lower alkyl), lower alkenyl and benzyl;
• R.sub.4 represents a radical selected from the group consisting of lower alkyl and furyl;
• and
• R.sub.5 represents a radical selected from the group consisting of phenyl, (lower alkyl) phenyl, nitrophenyl, halophenyl, and pyridyl,
• 4-oxides of the said compounds and acid addition salts of the said compounds and of their 4-oxides with pharmaceutically acceptable acids.