Cardenolide derivatives
AssigneeEtablissements Nativelle S.A.
InventorsFrancois-Xavier Jarreau, Roger Gerard Sarfati
Life of this patent
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Abstract
Cardiotonic cardenolide derivatives of the formula ##STR1## wherein n, m, R.sub.1 to R.sub.9 are as hereinafter defined, the mineral or organic salts thereof and a process for their preparation.
Claims9
Cardenolide derivatives having the general formula:
- ##STR4## in which n and m are the same or different and can be equal to 0, 1, 2, 3 or 4;
- R.sub.1, R.sub.2, R.sub.4, R.sub.5, and R.sub.6 are the same or different and denote a hydrogen atom or a hydroxy, alkoxy or acyloxy group;
- R.sub.3 denotes a lower alkyl, aldehyde, halo-alkyl, hydroxyalkyl, acyloxyalkyl or ethylene dioxyalkyl group;
- R.sub.7 denotes an hydrogen atom or an alkyl, alkyloxycarbonyl or aralkoxycarbonyl group;
- R.sub.8 denotes a hydrogen atom or an alkyl group;
- R.sub.9 denotes a hydroxy, alkoxy or aralkoxy group;
- and pharmaceutically acceptable mineral or organic salts of the aforementioned derivatives.
3.beta.-[.alpha.- or [.beta.-L-aspartyl]digitoxigenin and pharmaceutically acceptable mineral or organic salts thereof.
3.beta.-(.alpha.-L-glutamyl) digitoxigenin and pharmaceutically acceptable mineral or organic salts thereof.
3.beta.-[.alpha.- or [.beta.-(N-acetyl)-L-aspartyl] digitoxigenin and pharmaceutically acceptable mineral or organic salts thereof.
3.beta.-[.alpha.-(N-acetyl-.beta.-methyl)-L-aspartyl] digitoxigenin and pharmaceutically acceptable mineral or organic salts thereof.
3.beta.-(.alpha.-L-aspartyl) digoxigenin and pharmaceutically acceptable mineral or organic salts thereof.
Cardenolide derivatives having the general formula ##STR5## in which n and m are the same or different and can be equal to 0, 1, 2, 3 or 4;
- wherein R.sub.1, R.sub.2 and R.sub.5 denote a hydrogen atom or a hydroxy group;
- R.sub.3 denotes a lower alkyl, aldehyde or hydroxyalkyl group;
- R.sub.4 denotes a hydrogen atom;
- and R.sub.6 denotes a hydrogen atom, a hydroxy, alkoxy, or acyloxy group;
- R.sub.7 denotes an hydrogen atom or an alkyl, alkyloxycarbonyl or aralkoxycarbonyl group;
- R.sub.8 denotes a hydrogen atom or an alkyl group;
- R.sub.9 denotes a hydroxy, alkoxy or aralkoxy group;
- and pharmaceutically acceptable mineral or organic salts of the aforementioned derivatives.
Dependencies are inferred from the claim text.